Triplex dA_(10·)2dT_(10)

Factors influencing the stability of triplex DNA;

三链DNA稳定性的影响因素

DNA triple-helix formation is of great potential including selective control of gene expression, site-directed mutagenesis, gene repair, in situ chromosome labelling and other molecular diagnostics, thus the antigene strategy based on triplex DNA offers new therapeutic applications.

三链DNA技术具有可选择性调控基因的表达、基因的定点突变、基因的修复、原位染色体的标记和基因分子诊断等作用,因此以三链DNA为背景的反基因战略提供了治疗某些疾病的“新型药物”概念。