thymid kinase

Effect of Azidothymidine on irradiation-induced DNA single strand damage and repair of human glioma cell lines;

叠氮胸苷对人胶质瘤细胞辐射后DNA损伤单链修复的影响

Effects of excessive thymidine on the expression of cyclin;

过量胸苷对细胞周期素表达的影响

Zidovudine was synthesized from thymidine.

以胸苷为原料,5′位醇羟基用对甲氧基苯甲酸成酯保护,然后与偶氮二甲酸二乙酯和三苯基膦反应成"氧桥",再与叠氮化钠反应引入"叠氮"基团,最后脱保护得齐多夫定,总收率为67%。

MATERIALS AND METHODS:There were four groups:control group,azidothymidine group(HeLa cells were pretreated by 400 μmol/L Azidothymidine for 24 h),radiation group(HeL.

背景与目的:研究端粒酶抑制剂叠氮胸苷(Azidothymidine,AZT)对人宫颈癌HeLa细胞DNA放射性损伤修复的影响,探讨端粒酶在放射诱导的DNA损伤修复中的作用。