dichloropyrimidine dye

The compound 4 then reacted with sodium methoxide,methanol and 4,6-dichloropyrimidine in tetrahydrofuran to produce methyl(E)-2-[2-(6-chloropyrimidi.

首先以邻羟基苯乙酸(2)为原料与原甲酸三甲酯在醋酐中反应制备3-(α-甲氧基)-亚甲基苯并呋喃-2(3氢)-酮(4),收率59%;化合物4再与甲醇钠、4,6-二氯嘧啶在四氢呋喃中反应得到(E)-2-[2-(6-氯嘧啶-4-基氧基)苯基]-3-甲氧基丙烯酸甲酯(6),收率60%;化合物6与水杨腈反应得到嘧菌酯(1),收率81%。

4,6-Dihydroxypyrimidine was prepared from formamide and dimethyl malonate and then converted to 4,6-dichloropyrimidine (purity 98.

以甲酰胺、丙二酸二甲酯为原料合成4,6-二羟基嘧啶,然后采用三氯氧磷氯化法合成4,6-二氯嘧啶。

Guanidine nitrate and diethyl malonate were used as main materials to prepare 2-amino-4,6-dicarboxyl pyrimidine by cyclization,followed by chloridization to prepare 2-amino-4,6-dichloropyrimidine,and then by methoxidization to prepare 2-amino-4,6-dimethoxy pyrimidine.

以硝酸胍和丙二酸二乙酯为原料,经过环合生成2-氨基-4,6-二羟基嘧啶,氯化生成2-氨基-4,6-二氯嘧啶,再经甲氧基化得最终产品2-氨基-4,6-二甲氧基嘧啶。