Atemoyacin D (1) , a novel tetrahydroxy adjacent bis - tetrahydrofuranyl annonaceous acetogenin was isolated from the alcoholic extracts of Annona atemoya seeds and characterized by spectroscopic techniques,in addition to the known compounds, neo-annonin B (2) , neo-desacetyluvaricin (3),parviflorin (4) and annonacin (5).